Review
doi: 10.1016/0167-5699(93)90060-X.
The surrogate light chain in B-cell development
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- PMID: 8166770
- DOI: 10.1016/0167-5699(93)90060-X
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Review
The surrogate light chain in B-cell development
Immunol Today.
1993 Feb.
Abstract
The proteins encoded by the VpreB and lambda 5 genes associate with each other to form a light (L) chain-like structure, the surrogate L chain. It can form Ig-like complexes with three partners-the classical heavy (H) chain, the DHJHC mu-protein, or the newly discovered p55 chain; these are expressed on the surface of pre-B cells at different stages of development. Here, Fritz Melchers and colleagues review the structures of the VpreB and lambda 5 genes in mouse and their relatives in humans, describe their pattern of expression, and speculate on their possible evolution and functions.
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