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. 1994 Sep 15;203(2):1181-7.
doi: 10.1006/bbrc.1994.2307.

E5510 antagonizes thrombin receptor signals by inhibiting NF-kappa B activation

T Nakajima  1 , I Kitajima, H Shin, W Matsumoto, Y Soejima, I Maruyama
Affiliations

E5510 antagonizes thrombin receptor signals by inhibiting NF-kappa B activation

T Nakajima et al. Biochem Biophys Res Commun. .

Abstract

We have recently demonstrated that NF-kappa B is involved in a thrombin-signaling and that the antisense oligodeoxynucleotides (ODNs) of NF-kappa B has a marked inhibitory effect on thrombin-induced cellular responses. In this study, we demonstrate that E5510 (4-cyano-5,5-bis(methoxyphenyl)-4-pentenoic acid), a compound with anti-platelet activity preferentially inhibits the thrombin-inducible NF-kappa B activation and then antagonizes the following thrombin-induced cellular responses, proliferation and cytokines production in vascular smooth muscle cell, and the adherency of differentiated HL-60 cells. These data suggest that E5510 is an anti-atherosclerotic or anti-restenotic drug induced by thrombin.

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