doi: 10.1093/imammb/11.2.79.
Linkage analysis on complex pedigrees by simulation
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- PMID: 8089591
- DOI: 10.1093/imammb/11.2.79
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Linkage analysis on complex pedigrees by simulation
IMA J Math Appl Med Biol.
1994.
Abstract
A Markovian scheme for simulating the genotypes of individuals in a pedigree subject to constraints imposed by observed phenotypes is used to estimate the logarithm of a likelihood ratio in linkage analysis. The method is illustrated on a fictitious pedigree by comparison with exactly calculated results.
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