Review
doi: 10.1016/0168-9525(94)90135-x.
How flies make one equal two: dosage compensation in Drosophila
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- PMID: 7985243
- DOI: 10.1016/0168-9525(94)90135-x
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Review
How flies make one equal two: dosage compensation in Drosophila
Trends Genet.
1994 Oct.
Abstract
Dosage compensation is the process by which the expression of X-linked genes is equalized in males and females. In Drosophila, dosage compensation occurs by coordinately upregulating the transcription rates of all the genes on the single X chromosome in males. This hypertranscription requires the functioning of four autosomal male-specific lethal (msl) genes and is under the control of the Sxl gene. Recent genetic and molecular studies have suggested that the msl proteins may associate with one another in a sex-specific heteromeric complex on the male X chromosome, where they may function to alter its chromatin structure.
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