doi: 10.1099/0022-1317-33-2-321.
Antibody-induced redistribution of virus antigens on the surface of influenza virus-infected cells
- PMID: 792397
- DOI: 10.1099/0022-1317-33-2-321
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Antibody-induced redistribution of virus antigens on the surface of influenza virus-infected cells
J Gen Virol.
1976 Nov.
Abstract
The behaviour of virus-specific antigen-antibody complexes at the plasma membrane of HeLa cells infected with influenza virus (A0PR8) was studied by immunofluorescence- and immunoelectron-microscopy. As early as 7 h after infection the virus-induced plasma membrane antigens are evenly distributed over the surface of the infected cells. The addition of antiviral antibodies interferes with this distribution. The appearance of a subsequent patchlike and 'capping' distribution, followed by the disappearance of virus antigen-antibody complexes from the cell surface, is described. These findings demonstrate the potential mobility of virus-induced antigens in the plane of the cell surface.
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