Respiratory syncytial virus and allergic conjunctivitis
- PMID: 7897147
- DOI: 10.1016/s0091-6749(95)70169-9
Respiratory syncytial virus and allergic conjunctivitis
Abstract
The pathogenesis of allergic conjunctivitis is largely conjectural. We investigated the possible involvement of respiratory syncytial virus (RSV), a ubiquitous respiratory pathogen, in the development of allergic conjunctivitis through immune mechanisms. A new technique of brush cytology was used to obtain conjunctival cells from 30 patients with allergic conjunctivitis and 20 control subjects. Samples were assayed for the presence of RSV sequences with the reverse-transcription polymerase chain reaction and the nested polymerase chain reaction. Specific primers and inner primers were synthesized on the basis of RNA sequences previously identified. RSV sequences were detected in 7 of 30 (23%) patient samples and 1 of 20 (5%) control samples. Our results proved that polymerase chain reaction could detect RSV sequences in conjunctival samples. RSV may be a significant pathogenic factor in allergic conjunctivitis.
Similar articles
-
Respiratory syncytial virus and allergic conjunctivitis.Keio J Med. 1994 Dec;43(4):201-5. doi: 10.2302/kjm.43.201. Keio J Med. 1994. PMID: 7861690
-
Respiratory syncytial virus-induced interleukin-4 production by human conjunctival epithelial cells contributes to allergy: preliminary study.Curr Eye Res. 1998 Jun;17(6):656-62. Curr Eye Res. 1998. PMID: 9663856
-
Respiratory syncytial virus and chlamydia are not detectable by PCR in ongoing vernal keratoconjunctivitis.Ocul Immunol Inflamm. 2001 Dec;9(4):253-7. doi: 10.1076/ocii.9.4.253.3955. Ocul Immunol Inflamm. 2001. PMID: 11935435
-
Respiratory syncytial virus may be a pathogen in allergic conjunctivitis.Cornea. 2002 Mar;21(2 Suppl 1):S39-45. doi: 10.1097/00003226-200203001-00009. Cornea. 2002. PMID: 11995809
-
Respiratory syncytial virus persistence in chronic obstructive pulmonary disease.Pediatr Infect Dis J. 2008 Oct;27(10 Suppl):S63-70. doi: 10.1097/INF.0b013e3181684d67. Pediatr Infect Dis J. 2008. PMID: 18820581 Review.
Cited by
-
Extrapulmonary manifestations of severe respiratory syncytial virus infection--a systematic review.Crit Care. 2006;10(4):R107. doi: 10.1186/cc4984. Crit Care. 2006. PMID: 16859512 Free PMC article. Review.
-
Activation of cytokines and NF-kappa B in corneal epithelial cells infected by respiratory syncytial virus: potential relevance in ocular inflammation and respiratory infection.BMC Microbiol. 2004 Jul 15;4:28. doi: 10.1186/1471-2180-4-28. BMC Microbiol. 2004. PMID: 15256003 Free PMC article.
-
Influenza virus respiratory infection and transmission following ocular inoculation in ferrets.PLoS Pathog. 2012;8(3):e1002569. doi: 10.1371/journal.ppat.1002569. Epub 2012 Mar 1. PLoS Pathog. 2012. PMID: 22396651 Free PMC article.
-
Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections.Clin Microbiol Rev. 2018 Dec 12;32(1):e00042-18. doi: 10.1128/CMR.00042-18. Print 2019 Jan. Clin Microbiol Rev. 2018. PMID: 30541871 Free PMC article.
-
Viral infection of the lungs through the eye.J Virol. 2007 Jan;81(2):783-90. doi: 10.1128/JVI.01437-06. Epub 2006 Oct 18. J Virol. 2007. PMID: 17050596 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
