Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques
- PMID: 7892606
- DOI: 10.1126/science.7892606
Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques
Abstract
Adult macaques do not develop disease after infection with a nef deletion mutant of the simian immunodeficiency virus (SIV) and are protected against challenge with pathogenic virus. This finding led to the proposal to use nef-deleted viruses as live, attenuated vaccines to prevent human acquired immunodeficiency syndrome (AIDS). In contrast, neonatal macaques developed persistently high levels of viremia after oral exposure to and SIV nef, vpr, and negative regulatory element (NRE) deletion mutant. Severe hemolytic anemia, thrombocytopenia, and CD4+ T cell depletion were observed, indicating that neither nef nor vpr determine pathogenicity in neonates. Because such constructs have retained their pathogenic potential, they should not be used as candidate live, attenuated virus vaccines against human AIDS.
Comment in
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Attenuated retrovirus vaccines and AIDS.Science. 1995 Nov 17;270(5239):1218-9; author reply 1220-2. Science. 1995. PMID: 7502051 No abstract available.
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Attenuated retrovirus vaccines and AIDS.Science. 1995 Nov 17;270(5239):1219; author reply 1220-2. Science. 1995. PMID: 7502052 No abstract available.
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Attenuated retrovirus vaccines and AIDS.Science. 1995 Nov 17;270(5239):1219; author reply 1220-2. Science. 1995. PMID: 7502053 No abstract available.
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Attenuated retrovirus vaccines and AIDS.Science. 1995 Nov 17;270(5239):1219-20; author reply 1220-2. Science. 1995. PMID: 7502054 No abstract available.
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