Review
Human responses to bacterial endotoxin
Affiliations
- PMID: 7850934
Item in Clipboard
Review
Human responses to bacterial endotoxin
Circ Shock.
1994 Jul.
Abstract
The literature concerning human responses to bacterial endotoxin, in particular to the purified lipopolysaccharide derivative, has been critically reviewed and summarized. Papers selected for review are those that reported studies of human subjects in a normal state of health administered defined doses of either intravenous or aerosol inhaled material. Emphasis was placed on cardiovascular, pulmonary, metabolic, and inflammatory parameters. The information detailed here can be applied to understanding the pathophysiology of human consequences to spontaneous, clinical diseases induced by this highly inflammatory and ubiquitous substance.
Similar articles
-
Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist.J Pharmacol Exp Ther. 2003 Mar;304(3):1093-102. doi: 10.1124/jpet.102.044487. J Pharmacol Exp Ther. 2003. PMID: 12604686
-
N-acetylcysteine abrogates acute lung injury induced by endotoxin.Clin Exp Pharmacol Physiol. 2006 Jan-Feb;33(1-2):33-40. doi: 10.1111/j.1440-1681.2006.04320.x. Clin Exp Pharmacol Physiol. 2006. PMID: 16445696
-
N-acetyl cysteine attenuates acute lung injury in the rat.Shock. 1997 Dec;8(6):432-8. Shock. 1997. PMID: 9421857
-
Mediators of septic shock: new approaches for interrupting the endogenous inflammatory cascade.Crit Care Med. 1993 May;21(5):780-9. Crit Care Med. 1993. PMID: 8482101 Review.
-
Response of man to endotoxin.Immunobiology. 1993 Apr;187(3-5):403-16. doi: 10.1016/S0171-2985(11)80353-0. Immunobiology. 1993. PMID: 8330905 Review.
Cited by
-
Cyanobacterial lipopolysaccharides and human health - a review.Environ Health. 2006 Mar 24;5:7. doi: 10.1186/1476-069X-5-7. Environ Health. 2006. PMID: 16563160 Free PMC article. Review.
-
Health effects among workers in sewage treatment plants.Occup Environ Med. 1999 May;56(5):354-7. doi: 10.1136/oem.56.5.354. Occup Environ Med. 1999. PMID: 10472311 Free PMC article.
-
Effects of recombinant human activated protein C in human models of endotoxin administration.Proc Am Thorac Soc. 2005;2(3):243-7. doi: 10.1513/pats.200501-004AC. Proc Am Thorac Soc. 2005. PMID: 16222045 Free PMC article. Review.
-
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4).J Exp Med. 1999 Feb 15;189(4):615-25. doi: 10.1084/jem.189.4.615. J Exp Med. 1999. PMID: 9989976 Free PMC article.
-
Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes.J Exp Med. 1996 Jul 1;184(1):51-60. doi: 10.1084/jem.184.1.51. J Exp Med. 1996. PMID: 8691149 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources