Fatty acids and adipose cell differentiation
- PMID: 7784445
- DOI: 10.1016/0952-3278(95)90008-x
Fatty acids and adipose cell differentiation
Abstract
Fatty acids are important metabolic substrates for adipose tissue. In preadipose cells, fatty acids are also potent inducers of various genes encoding proteins directly involved in fatty acid metabolism. On a longer-term basis, fatty acids induce the terminal differentiation of preadipose to adipose cells. Fatty acids act primarily at a transcriptional level. A member of the steroid/thyroid hormone receptor superfamily has been identified by cDNA cloning from a mouse Ob1771 preadipose cell library. This receptor is likely the fatty acid-activated receptor implicated in the transcriptional effects of fatty acids in adipose cells. Thus fatty acids appear to play a new role as signal transducing molecules which are involved in adipose cell differentiation.
Similar articles
-
Fatty acids as signal transducing molecules: involvement in the differentiation of preadipose to adipose cells.J Lipid Res. 1994 May;35(5):930-7. J Lipid Res. 1994. PMID: 8071615
-
Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation.J Biol Chem. 2000 Dec 8;275(49):38768-73. doi: 10.1074/jbc.M006450200. J Biol Chem. 2000. PMID: 10991946
-
Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.Mol Pharmacol. 1994 Dec;46(6):1070-6. Mol Pharmacol. 1994. PMID: 7808426
-
Trans-differentiation of myoblasts to adipoblasts: triggering effects of fatty acids and thiazolidinediones.Prostaglandins Leukot Essent Fatty Acids. 1997 Jul;57(1):71-5. doi: 10.1016/s0952-3278(97)90495-6. Prostaglandins Leukot Essent Fatty Acids. 1997. PMID: 9250611 Review.
-
The adipose conversion process: regulation by extracellular and intracellular factors.Reprod Nutr Dev. 2000 Jul-Aug;40(4):325-58. doi: 10.1051/rnd:2000103. Reprod Nutr Dev. 2000. PMID: 11081662 Review.
Cited by
-
Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity.Pediatr Nephrol. 2010 Apr;25(4):669-77. doi: 10.1007/s00467-009-1407-3. Epub 2009 Dec 22. Pediatr Nephrol. 2010. PMID: 20033220 Review.
-
Modulation of adipocyte lipogenesis by octanoate: involvement of reactive oxygen species.Nutr Metab (Lond). 2006 Jul 27;3:30. doi: 10.1186/1743-7075-3-30. Nutr Metab (Lond). 2006. PMID: 16872526 Free PMC article.
-
Elucidation of a promoter activity that directs the expression of acetyl-CoA carboxylase alpha with an alternative N-terminus in a tissue-restricted fashion.Biochem J. 1998 Jul 1;333 ( Pt 1)(Pt 1):17-25. doi: 10.1042/bj3330017. Biochem J. 1998. PMID: 9639557 Free PMC article.
-
Oleate-induced formation of fat cells with impaired insulin sensitivity.Lipids. 2006 Mar;41(3):267-71. doi: 10.1007/s11745-006-5096-4. Lipids. 2006. PMID: 16711601
-
Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map.Front Endocrinol (Lausanne). 2022 Dec 16;13:1017832. doi: 10.3389/fendo.2022.1017832. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36589834 Free PMC article.