The biosynthesis of oncovirus proteins
- PMID: 77678
- DOI: 10.1016/0304-419x(78)90014-8
The biosynthesis of oncovirus proteins
Abstract
The patterns of oncovirus protein biosynthesis are essentially similar for avian and mammalian viruses. In each case the four major internal structural proteins are synthesized as a precursor polypeptide of about 75 000 daltons, the product of the gag gene. Translation occurs on genome-sized mRNA. This polyprotein is cleaved in a series of steps to give the mature proteins. The mechanism and localization of cleavage have not yet been clarified. Viral reverse transcriptase, the product of the pol gene, also is translated on genome-sized mRNA as a precursor, which is a "read-through" product of the neighbouring gag gene. The two major envelope proteins are translated as a glycosylated precursor of apparent molecular weight about 90 000 from the env gene located on a sub-genomic RNA species. The precursor is transported to the plasma membrane where it may mark the site of virus budding. It is cleaved in transport or on the membrane, but the resulting two mature envelope proteins remain tied by disulfide bonds. Sarc, the protein product of the src gene that is responsible for transformation, is translated from a different viral mRNA than the structural proteins. Sarc has not been definitively characterized in any system.
Similar articles
-
A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase.Cell. 1977 Dec;12(4):993-1005. doi: 10.1016/0092-8674(77)90164-7. Cell. 1977. PMID: 74287
-
Translation of avian type C virus messenger RNA: evidence for multiple initiation sites.Virology. 1977 Oct 15;82(2):255-64. doi: 10.1016/0042-6822(77)90001-0. Virology. 1977. PMID: 72449 No abstract available.
-
Characterization of viral polyproteins in cells transformed and producing Moloney murine sarcoma virus-124.Biochim Biophys Acta. 1980 Jul 29;608(2):215-31. doi: 10.1016/0005-2787(80)90168-9. Biochim Biophys Acta. 1980. PMID: 6156703
-
Structure and morphogenesis of type-C retroviruses.Adv Cancer Res. 1978;28:63-89. doi: 10.1016/s0065-230x(08)60646-6. Adv Cancer Res. 1978. PMID: 81604 Review. No abstract available.
-
[Tumorgenesis due to oncovirus: special reference to avian sarcoma viruses (review) (author's transl)].Uirusu. 1981 Dec;31(2):123-44. Uirusu. 1981. PMID: 6278753 Review. Japanese. No abstract available.
Cited by
-
c-erbA encodes multiple proteins in chicken erythroid cells.Mol Cell Biol. 1988 Oct;8(10):4155-61. doi: 10.1128/mcb.8.10.4155-4161.1988. Mol Cell Biol. 1988. PMID: 3054510 Free PMC article.
-
A deletion mutation in the 5' part of the pol gene of Moloney murine leukemia virus blocks proteolytic processing of the gag and pol polyproteins.J Virol. 1985 Mar;53(3):899-907. doi: 10.1128/JVI.53.3.899-907.1985. J Virol. 1985. PMID: 3882995 Free PMC article.
-
Infectivity of proviral DNA from avian sarcoma virus-transformed mammalian cells.J Virol. 1979 Mar;29(3):833-9. doi: 10.1128/JVI.29.3.833-839.1979. J Virol. 1979. PMID: 221676 Free PMC article.
-
Post-translational modification of Rauscher leukemia virus precursor polyproteins encoded by the gag gene.J Virol. 1979 Apr;30(1):255-66. doi: 10.1128/JVI.30.1.255-266.1979. J Virol. 1979. PMID: 480454 Free PMC article.
-
Evidence for two dissimilar polypeptide chains in the beta 2 subunit of hexosaminidase.Proc Natl Acad Sci U S A. 1982 Mar;79(5):1602-5. doi: 10.1073/pnas.79.5.1602. Proc Natl Acad Sci U S A. 1982. PMID: 6951199 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
