Measuring inhalant nitrite exposure in gay men: implications for elucidating the etiology of AIDS-related Kaposi's sarcoma
- PMID: 7744258
- DOI: 10.1007/BF01435007
Measuring inhalant nitrite exposure in gay men: implications for elucidating the etiology of AIDS-related Kaposi's sarcoma
Abstract
We reviewed 12 epidemiologic studies conducted among gay men with AIDS to examine the role of potential 'cofactors' in the development of KS. Aspects of the studies reviewed include basic study design, wording of the questionnaires, and published results comparing KS patients with those who developed opportunistic infections indicative of AIDS. The studies included questions about sociodemographics, medical history, use of drugs, travel, and sexual behaviors. Patients were invited to provide blood and/or other specimens for laboratory analysis. The results of the review of epidemiologic studies are inconclusive. Nitrite inhalant use was a variable often associated with KS (five studies). The differences in outcomes of these studies may reflect differences in study designs, sample sizes, timing, quality, and content of interviews regarding nitrites, sexual behaviours and other potential cofactors. Epidemiologic study with careful consideration to content of questionnaires and laboratory testing may yet reveal the causes or cofactors for this tumor.
Similar articles
-
Epidemiologic studies--Kaposi's sarcoma vs. opportunistic infections among homosexual men with AIDS.NIDA Res Monogr. 1988;83:96-105. NIDA Res Monogr. 1988. PMID: 3140024 Review. No abstract available.
-
The search for cofactors in AIDS, including an analysis of the association of nitrite inhalant abuse and Kaposi's sarcoma.Prog Clin Biol Res. 1990;325:93-102. Prog Clin Biol Res. 1990. PMID: 2405412 Review.
-
Nitrite inhalants: history, epidemiology, and possible links to AIDS.Environ Health Perspect. 1994 Oct;102(10):858-61. doi: 10.1289/ehp.94102858. Environ Health Perspect. 1994. PMID: 9644194 Free PMC article. Review.
-
Nitrite inhalants: historical perspective.NIDA Res Monogr. 1988;83:1-14. NIDA Res Monogr. 1988. PMID: 3140018 Review.
-
Nitrite inhalant abuse and AIDS-related Kaposi's sarcoma.J Acquir Immune Defic Syndr (1988). 1990;3 Suppl 1:S47-50. J Acquir Immune Defic Syndr (1988). 1990. PMID: 2395087
Cited by
-
Multifactorial etiology of Kaposi' sarcoma: a hypothesis.J Biosci. 2008 Dec;33(5):643-51. doi: 10.1007/s12038-008-0084-x. J Biosci. 2008. PMID: 19179752 No abstract available.
-
Long-term nitrite inhalant exposure and cancer risk in MSM.AIDS. 2017 May 15;31(8):1169-1180. doi: 10.1097/QAD.0000000000001451. AIDS. 2017. PMID: 28441176 Free PMC article.
-
The chemical bases of the various AIDS epidemics: recreational drugs, anti-viral chemotherapy and malnutrition.J Biosci. 2003 Jun;28(4):383-412. doi: 10.1007/BF02705115. J Biosci. 2003. PMID: 12799487
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical