Review
doi: 10.1016/0165-2478(94)00159-6.
The bio-logical role of invariant chain (Ii) in MHC class II antigen presentation
Affiliations
- PMID: 7737689
- DOI: 10.1016/0165-2478(94)00159-6
Item in Clipboard
Review
The bio-logical role of invariant chain (Ii) in MHC class II antigen presentation
Immunol Lett.
1994 Dec.
Abstract
Foreign antigens are internalized by antigen presenting cells by endocytosis and processed to peptides. To enable presentation of antigenic peptides by MHC class II molecules, these molecules have to be sorted to endosomal compartments where they can meet and bind the peptides. Invariant chain is complexed with MHC class II molecules and contains sorting signals responsible for MHC class II accumulation in endosomes. Invariant chain also has several other features contributing to the immune system's specific combat against invaders.
Similar articles
-
Endosomal localization of MHC class II-invariant chain complexes.Immunol Res. 1994;13(4):244-52. doi: 10.1007/BF02935616. Immunol Res. 1994. PMID: 7616052 Review.
-
Efficient internalization of MHC class II-invariant chain complexes is not sufficient for invariant chain proteolysis and class II antigen presentation.J Immunol. 1995 Jul 15;155(2):630-43. J Immunol. 1995. PMID: 7608541
-
MHC class II antigen processing: biology of invariant chain.Curr Opin Immunol. 1994 Feb;6(1):57-63. doi: 10.1016/0952-7915(94)90034-5. Curr Opin Immunol. 1994. PMID: 8172680 Review.
-
Exogenous CLIP localizes into endocytic compartment of cells upon internalization: implications for antigen presentation by MHC class II molecules.Mol Immunol. 2008 Apr;45(8):2166-76. doi: 10.1016/j.molimm.2007.12.016. Epub 2008 Feb 15. Mol Immunol. 2008. PMID: 18279957
-
Phosphorylation of the invariant chain by protein kinase C regulates MHC class II trafficking to antigen-processing compartments.J Immunol. 1999 Nov 15;163(10):5435-43. J Immunol. 1999. PMID: 10553069
Cited by
-
Antagonism of major histocompatibility complex class II invariant chain peptide during chronic lipopolysaccharide treatment rescues autoregulatory behavior.Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F957-F966. doi: 10.1152/ajprenal.00164.2019. Epub 2019 Aug 21. Am J Physiol Renal Physiol. 2019. PMID: 31432707 Free PMC article.
-
Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.Immunology. 1999 Mar;96(3):473-84. doi: 10.1046/j.1365-2567.1999.00676.x. Immunology. 1999. PMID: 10233730 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
