Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Apr;95(4):1741-6.
doi: 10.1172/JCI117851.

Immune predispositions for cytomegalovirus retinitis in AIDS. The HNRC Group

R D Schrier  1 , W R Freeman, C A Wiley, J A McCutchan
Affiliations

Immune predispositions for cytomegalovirus retinitis in AIDS. The HNRC Group

R D Schrier et al. J Clin Invest. 1995 Apr.

Abstract

CMV retinitis develops in approximately 28-35% of all AIDS patients at later stages of disease, often leading to blindness. To determine whether the subset of AIDS patients who developed CMV retinitis (CMV-R) were immunologically predisposed, T cell proliferation responses to CMV were examined prospectively in an HIV infected, HLA typed, longitudinal study population. Individuals who developed CMV-R had significantly lower T cell proliferation responses to CMV, both early and late in disease, compared to CD4 matched controls who have not developed CMV-R. Since HLA proteins influence T-cell recognition, phenotypes of 21 CMV-R patients were examined to determine whether certain HLA alleles were associated with low immune response and predisposed AIDS patients to CMV-R. HLA DR7 and B44 were at increased (nearly twice the expected) frequency in those with CMV-R. The combined association of either B44, 51 or DR7 with CMV-R was highly significant (P = .008, relative risk of CMV-R = 15) with correction for multiple comparisons. Low immune responses were twice as frequent in those with (61%) compared to those without (30%) predisposing alleles. Thus, AIDS patients with immunogenetically related hyporesponsiveness to CMV antigens may be at increased risk of retinitis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Acquir Immune Defic Syndr. 1991;4(8):814-8 - PubMed
    1. Clin Exp Immunol. 1990 Dec;82(3):559-66 - PubMed
    1. DNA Seq. 1991;2(1):1-12 - PubMed
    1. Ophthalmology. 1992 Sep;99(9):1377-84 - PubMed
    1. J Infect Dis. 1992 Dec;166(6):1228-35 - PubMed

Publication types