[Genetic regulation of human genital papillomaviruses]
- PMID: 7676352
[Genetic regulation of human genital papillomaviruses]
Abstract
Human papillomavirus (HPV) specifically infect stratified epithelial cells, causing benign and malignant neoplasia. Several elements directing this virus' genetic expression are present in a non-coding region called LCR. HPV infection starts in the basal cells of stratified epithelia, where a particular combination of cellular factors interacting with the LCR starts the transcription of the viral E6 and E7 oncogenes. The E6 and E7 genes alter the cell cycle because they interact and inactivate tumor suppressor proteins: E6 binds and degrades protein p53 and E7 associates with p105RB. E1 and E2 are the next synthesized proteins. E2 blocks the early transcription and permits E1 specific binding to the viral origin of replication located within the LCR, initiating the viral genome replication. Following the course of viral infection, the E2-induced E6 and E7 down-regulation releases p53 and p105RB proteins, and the differentiation process can continue. Then, a putative late promoter can activate the capsid genes L1 and L2. At this step, mature virions can be detected in the upper layers of the epithelium. Disruption in E2 gene transcription is usually associated to genital malignant neoplasia. In the absence of E2, E6 and E7 remain constitutively expressed, sustaining the immortality of the infected cell and blocking the epithelial differentiation program.
Similar articles
-
[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus].Rev Invest Clin. 2002 May-Jun;54(3):231-42. Rev Invest Clin. 2002. PMID: 12183893 Review. Spanish.
-
Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells.Gynecol Oncol. 2001 Feb;80(2):168-75. doi: 10.1006/gyno.2000.6053. Gynecol Oncol. 2001. PMID: 11161855
-
Cellular and molecular alterations in human epithelial cells transformed by recombinant human papillomavirus DNA.Crit Rev Oncog. 1993;4(4):337-60. Crit Rev Oncog. 1993. PMID: 8394744 Review.
-
The role of HPV oncoproteins and cellular factors in maintenance of hTERT expression in cervical carcinoma cells.Gynecol Oncol. 2004 Jul;94(1):40-7. doi: 10.1016/j.ygyno.2004.03.041. Gynecol Oncol. 2004. PMID: 15262117
-
Comparative study on E6 and E7 genes of some cutaneous and genital papillomaviruses of human origin for their ability to transform 3Y1 cells.Virology. 1993 Jan;192(1):102-11. doi: 10.1006/viro.1993.1012. Virology. 1993. PMID: 8390746
Publication types
MeSH terms
LinkOut - more resources
Medical
Research Materials
Miscellaneous