Review
doi: 10.1016/s0968-0004(00)89056-8.
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
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- PMID: 7667888
- DOI: 10.1016/s0968-0004(00)89056-8
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Review
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
Trends Biochem Sci.
1995 Aug.
Abstract
Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence between two major cellular signalling systems: those involving G-protein-coupled receptors and those involving receptor tyrosine kinases. Importantly, wortmannin can enter intact cells, making whole-cell studies of the above signalling pathways possible.
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