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Comparative Study
. 1995 May;36(2-3):247-57.
doi: 10.1016/0168-1702(95)00008-e.

Sequence and in vitro expression of the phosphoprotein gene of avian pneumovirus

R Ling  1 , P J Davis, Q Yu, C M Wood, C R Pringle, D Cavanagh, A J Easton
Affiliations
Comparative Study

Sequence and in vitro expression of the phosphoprotein gene of avian pneumovirus

R Ling et al. Virus Res. 1995 May.

Abstract

The phosphoprotein (P) gene of two subgroup A strains of avian pneumovirus comprised 855 nucleotides containing only one substantial open reading frame encoding a protein of 278 amino acids, with a predicted M(r) of 30,323. In vitro translation of P mRNA in a wheat germ system resulted in the synthesis of two polypeptides of M(r) 35,000. Comparison of the deduced P protein sequence with that of the known mammalian pneumoviruses revealed overall amino acid identities ranging from 31 to 34.5%, suggesting a distant relationship. However, there was a much higher identity (63.2-68.4%) in a region of 57 residues, which included a heptad repeat sequence.

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