Lipids of matrix vesicles
- PMID: 765160
Lipids of matrix vesicles
Abstract
The association of lipids with biological mineral formation was first indicated by histochemical observations. This was later confirmed by biochemical studies which revealed that calcium was bound to acidic lipids at sites of early mineral deposition. The morphological locus of initial mineral formation has now been shown to be membrane-enclosed vesicles in the extracellular matrix. Recent studies on isolated vesicles have documented that they are rich in lipids very similar to those previously found to be associated with newly forming mineral. The vesicle lipids are enriched in cholesterol, free fatty acids, sphingomyelin, glycolipids, lysophospholipids, and phosphatidylserine, and depleted in phosphatidylcholine and -ethanolamine. This composition is like that of the plasma membrane of cells and supports electron microscopic evidence that the vesicles arise by budding from the chondrocyte surface membrane. Metabolic studies indicate that formation of the vesicles occurs relatively rapidly (i.e., in less than 6 hours) by biochemical processes involving both lipid synthesis and degradation. In vitro studies suggest that the vesicle lipids may be involved in the initial binding and phase separation of calcium phosphate, as well as its conversion to crystalline apatite; however, final elucidation of the mechanism of action remains to be attained.
Similar articles
-
Role of lipids in calcification of cartilage.Anat Rec. 1989 Jun;224(2):211-9. doi: 10.1002/ar.1092240210. Anat Rec. 1989. PMID: 2672885 Review.
-
Acidic lipids associated with the local mechanism of calcificaiton: a review.Clin Orthop Relat Res. 1976 Jul-Aug;(118):231-41. Clin Orthop Relat Res. 1976. PMID: 954280
-
Lipid composition of isolated epiphyseal cartilage cells, membranes and matrix vesicles.Biochim Biophys Acta. 1975 Oct 21;409(1):128-43. doi: 10.1016/0005-2760(75)90087-9. Biochim Biophys Acta. 1975. PMID: 1182191
-
Separation and quantification of chicken and bovine growth plate cartilage matrix vesicle lipids by high-performance liquid chromatography using evaporative light scattering detection.Anal Biochem. 2003 Nov 1;322(1):104-15. doi: 10.1016/S0003-2697(03)00462-7. Anal Biochem. 2003. PMID: 14705786
-
Biophysical aspects of lipid interaction with mineral: liposome model studies.Anat Rec. 1989 Jun;224(2):220-5. doi: 10.1002/ar.1092240211. Anat Rec. 1989. PMID: 2672886 Review.
Cited by
-
Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges.Front Cardiovasc Med. 2018 Nov 23;5:172. doi: 10.3389/fcvm.2018.00172. eCollection 2018. Front Cardiovasc Med. 2018. PMID: 30533416 Free PMC article. Review.
-
Thallium chondrodystrophy in chick embryos: ultrastructural changes in the epiphyseal plate.Calcif Tissue Int. 1981;33(1):57-69. doi: 10.1007/BF02409413. Calcif Tissue Int. 1981. PMID: 6780156
-
An ultrastructural study of calcium phosphate formation in multilamellar liposome suspensions.Calcif Tissue Int. 1987 Oct;41(4):192-201. doi: 10.1007/BF02555238. Calcif Tissue Int. 1987. PMID: 3119175
-
Effects of bioactive lipids and lipoproteins on bone.Trends Endocrinol Metab. 2014 Feb;25(2):53-9. doi: 10.1016/j.tem.2013.10.001. Epub 2013 Oct 30. Trends Endocrinol Metab. 2014. PMID: 24183940 Free PMC article. Review.
-
Primary mineralization in the interface between bone and methyl methacrylate implants in rat mandibles. A correlative light and scanning and transmission electron microscope study.Arch Orthop Trauma Surg (1978). 1983;101(3):171-6. doi: 10.1007/BF00436766. Arch Orthop Trauma Surg (1978). 1983. PMID: 6870504