doi: 10.1038/376785a0.
Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
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- PMID: 7651539
- DOI: 10.1038/376785a0
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Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
Nature.
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Abstract
The product of the c-abl gene is a non-receptor tyrosine kinase that is localized to the nucleus and cytoplasm. The precise function of c-Abl is unknown. Here we show that ionizing radiation activates c-Abl. Similar results were obtained with the alkylating agents cis-platinum and mitomycin C. We also demonstrate that cells deficient in c-Abl fail to activate Jun kinase (JNK/SAP kinase) after ionizing radiation or alkylating agent exposure and that reconstitution of c-Abl in these cells restores that response. In contrast, the stress response to tumour-necrosis factor is stimulated by a c-Abl-independent mechanism. These findings indicate that c-abl is involved in the stress response to DNA-damaging agents.
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