Review
doi: 10.1016/0014-5793(95)00551-j.
Heads or tails--what determines the orientation of proteins in the membrane
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- PMID: 7641889
- DOI: 10.1016/0014-5793(95)00551-j
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Review
Heads or tails--what determines the orientation of proteins in the membrane
FEBS Lett.
.
Free article
Abstract
The same translocation machinery in the endoplasmic reticulum translocates either the N-or the C-terminal domain of signal-anchor proteins across the membranes. Charged residues flanking the signal sequence are important to determine which end is translocated, but are not sufficient to generate a uniform topology. The folding state of the N-terminal segment, which is to be translocated posttranslationally, and the length or hydrophobicity of the signal sequence are additional criteria to determine protein orientation in the membrane.
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