Review
doi: 10.1146/annurev.med.46.1.257.
Novel antithrombotic therapeutics targeted against platelet glycoprotein IIb/IIIa
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- PMID: 7598462
- DOI: 10.1146/annurev.med.46.1.257
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Review
Novel antithrombotic therapeutics targeted against platelet glycoprotein IIb/IIIa
Annu Rev Med.
1995.
Abstract
Platelet aggregation is one of the best understood examples of adhesive cell-cell interactions. The platelet glycoprotein IIb/IIIa membrane receptor plays a pivotal role in platelet aggregation through its binding of fibrinogen. It is intimately involved in the pathogenesis of platelet-rich arterial thromboses. The IIb/IIIa receptor is an important target for recently described novel antiplatelet therapeutics. The development and clinical evaluation of this class of antiplatelet therapeutics are reviewed in this article.
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