Review
doi: 10.1146/annurev.med.46.1.223.
Advanced protein glycosylation in diabetes and aging
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- PMID: 7598459
- DOI: 10.1146/annurev.med.46.1.223
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Review
Advanced protein glycosylation in diabetes and aging
Annu Rev Med.
1995.
Abstract
Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress.
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