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Review
. 1995 Jun;7(3):143-54.
doi: 10.1016/1044-5323(95)90042-x.

In-vitro models of B-lineage commitment

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Review

In-vitro models of B-lineage commitment

B L Kee et al. Semin Immunol. 1995 Jun.

Abstract

The development of mature B lymphocytes from multipotent progenitors follows a pathway of differentiation marked by a progressive restriction in lineage options. The requirements for progression through the B lineage developmental pathway have been investigated intensively and a number of critical components of the differentiation process have been identified. However, the genetic basis for lineage determination remains unresolved. Recently, a number of in-vitro assays have been established which support the development of committed B cell progenitors from multipotent cells. These assays have provided a novel system in which the process of B lineage commitment can be followed and manipulated. In this review we present a model of B-lineage progression from multipotent progenitors to committed B-cell progenitors and discuss potential mediators of the commitment process.

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