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Review
. 1994 Sep-Oct;12(5):553-9.

Apoptosis in SLE--too little or too much?

K B Elkon  1
Affiliations
  • PMID: 7531124
Review

Apoptosis in SLE--too little or too much?

K B Elkon. Clin Exp Rheumatol. 1994 Sep-Oct.

Abstract

Cells of the immune system are, most likely, programmed to die unless recruited into an immune response. An active cell death program may also be induced by a variety of soluble and surface signals, many of which have only recently been recognized. The importance of these pathways in maintaining tolerance is highlighted by the development of lupus-like diseases in three different mouse strains that have spontaneous mutations in the Fas/APO-1 receptor or its ligand. The known function of Fas/APO-1 in signalling apoptosis explains the persistence of self reactive cells in lpr mice although it is unclear, at present, whether Fas defects effect both central and peripheral tolerance. Whereas Fas/APO-1 receptor expression appears to be normal in humans with SLE, other defects in the Fas/APO-1 pathway or other key molecules in the cell death survival require further study.

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