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. 1994 Jul 8;265(5169):259-62.
doi: 10.1126/science.7517575.

Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium

S P Balk  1 , S Burke, J E Polischuk, M E Frantz, L Yang, S Porcelli, S P Colgan, R S Blumberg
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Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium

S P Balk et al. Science. .

Abstract

A major histocompatibility complex class Ib protein, CD1d, is expressed by human intestinal epithelial cells (IECs) and is a ligand for CD8+ T cells. CD1d was found to be expressed on the surface of human IECs as a 37-kilodalton protein that was beta 2-microglobulin (beta 2M) independent with no N-linked carbohydrate. Transfection into a beta 2M- cell line confirmed that CD1d could be expressed at the cell surface in the absence of beta 2M. These data indicate that IECs use a specialized pathway for CD1d synthesis and that a beta 2M-independent class Ib protein may be the normal ligand for some intestinal T cells.

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