Review
doi: 10.1016/0166-2236(93)90193-p.
Structure and function of voltage-gated ion channels
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- PMID: 7509519
- DOI: 10.1016/0166-2236(93)90193-p
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Review
Structure and function of voltage-gated ion channels
Trends Neurosci.
1993 Dec.
Abstract
The principal subunits of the voltage-gated Na+, Ca2+ and K+ channels are members of a related gene family and are functionally autonomous in voltage-dependent activation, ion conductance and inactivation. In this article, recent work locating the structural elements that are responsible for these three basic functions of the voltage-gated ion channels is reviewed. These studies reveal strong functional analogies among the different ion channels and suggest that the striking differences in their properties arise as variations on a common structural and functional theme.
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