Review
doi: 10.1098/rstb.1993.0130.
Interactions of CD4 with MHC class II molecules, T cell receptors and p56lck
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- PMID: 7506833
- DOI: 10.1098/rstb.1993.0130
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Review
Interactions of CD4 with MHC class II molecules, T cell receptors and p56lck
Philos Trans R Soc Lond B Biol Sci.
.
Abstract
CD4 and CD8 are members of the immunoglobulin supergene family of proteins, and function as co-receptors with the T cell receptor (TCR) in binding MHC class II or class I molecules, respectively. Within this multimeric complex, CD4 interacts with three distinct ligands. CD4 interacts through its D1 and D2 domains with MHC class II proteins, through its D3 and D4 domains with T cell receptors, and through its cytoplasmic tail with p56lck, a src-related, protein tyrosine kinase. Each of these interactions is important in the function of CD4 and will be discussed in turn.
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