doi: 10.1126/science.270.5239.1197.
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine
Affiliations
- PMID: 7502044
- DOI: 10.1126/science.270.5239.1197
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Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine
Science.
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Abstract
The efficacy of pre- and postexposure treatment with the antiviral compound (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) was tested against simian immunodeficiency virus (SIV) in macaques as a model for human immunodeficiency virus (HIV). PMPA was administered subcutaneously once daily beginning either 48 hours before, 4 hours after, or 24 hours after virus inoculation. Treatment continued for 4 weeks and the virologic, immunologic, and clinical status of the macaques was monitored for up to 56 weeks. PMPA prevented SIV infection in all macaques without toxicity, whereas all control macaques became infected. These results suggest a potential role for PMPA prophylaxis against early HIV infection in cases of known exposure.
Comment in
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AIDS research. New drug shows promise in monkeys.Science. 1995 Nov 17;270(5239):1121-2. doi: 10.1126/science.270.5239.1121. Science. 1995. PMID: 7502035 No abstract available.
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The role of tenofovir in the prevention of HIV infections.AIDS. 2006 Oct 3;20(15):1990-1. doi: 10.1097/01.aids.0000247128.27505.28. AIDS. 2006. PMID: 16988528 No abstract available.
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