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. 1995 Nov 21;92(24):11264-8.
doi: 10.1073/pnas.92.24.11264.

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

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Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

A Schulze et al. Proc Natl Acad Sci U S A. .

Abstract

Cyclin A is involved in the control of S phase and mitosis in mammalian cells. Expression of the cyclin A gene in nontransformed cells is characterized by repression of its promoter during the G1 phase of the cell cycle and its induction at S-phase entry. We show that this mode of regulation is mediated by the transcription factor E2F, which binds to a specific site in the cyclin A promoter. It differs from the prototype E2F site in nucleotide sequence and protein binding; it is bound by E2F complexes containing cyclin E and p107 but not pRB. Ectopic expression of cyclin D1 triggers premature activation of the cyclin A promoter by E2F, and this effect is blocked by the tumor suppressor protein p16INK4.

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References

    1. Proc Natl Acad Sci U S A. 1987 Jan;84(2):388-92 - PubMed
    1. Science. 1990 Nov 9;250(4982):786-91 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3685-9 - PubMed
    1. Cell. 1993 May 7;73(3):499-511 - PubMed
    1. Genes Dev. 1993 May;7(5):812-21 - PubMed

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