doi: 10.1111/j.1432-1033.1981.tb05303.x.
The amino-acid sequence of the alpha subunit in bovine brain S-100a protein
- PMID: 7250124
- DOI: 10.1111/j.1432-1033.1981.tb05303.x
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The amino-acid sequence of the alpha subunit in bovine brain S-100a protein
Eur J Biochem.
1981 May.
Free article
Abstract
The brain specific S-100 protein is a mixture of two components S-100a and S-100b with a subunit composition alpha beta or beta 2 respectively. The amino acid sequence of the beta subunit has been previously determined. This paper presents the sequence of the alpha subunit in the S-100a protein. The alpha subunit consists of 93 amino-acid residues and has a relative molecular mass of 10,400. The sequence shows extensive homology (58%) with that of the beta-subunit and shares an apparent calcium binding site in the C-terminal half of the molecule, suggesting a close evolutionary relationship between these subunits.
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