Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis
- PMID: 7233190
- DOI: 10.1126/science.7233190
Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis
Abstract
The molecularly cloned, long terminal repeat (LTR) of the Moloney sarcoma virus (M-MSV) provirus has been covalently linked to c-mos, the cellular homolog of the M-MSV-specific sequence, v-mos. These newly constructed clones lack any M-MSV-derived sequences other than the LTR, but in DNA transfection assays they transform cells as efficiently as cloned subgenomic M-MSV fragments containing both v-mos and LTR. Cells transformed by LTR:c-mos hybrid molecules contain additional copies of mos DNA, and several size classes of polyadenylated RNA's with sequence homology to mos. The activation of the transforming potential of c-mos by the proviral LTR suggests a model whereby LTR-like elements could activate other normal cell sequences with oncogenic potential.
Similar articles
-
Sequences in the long terminal repeats of the Moloney murine sarcoma virus-124 genome which control transforming gene function.Virology. 1984 Aug;137(1):32-40. doi: 10.1016/0042-6822(84)90005-9. Virology. 1984. PMID: 6089418
-
Long terminal repeat enhancement of v-mos transforming activity: identification of essential regions.J Virol. 1983 Jun;46(3):726-36. doi: 10.1128/JVI.46.3.726-736.1983. J Virol. 1983. PMID: 6190012 Free PMC article.
-
Molecularly cloned c-mos(rat) is biologically active.EMBO J. 1982;1(11):1313-7. doi: 10.1002/j.1460-2075.1982.tb01316.x. EMBO J. 1982. PMID: 6327263 Free PMC article.
-
Demonstration of biological activity and nucleotide sequence of an in vitro synthesized clone of the Moloney murine sarcoma virus mos gene.J Virol. 1982 May;42(2):538-46. doi: 10.1128/JVI.42.2.538-546.1982. J Virol. 1982. PMID: 7045395 Free PMC article.
-
Isolation of a transformation-defective deletion mutant of Moloney murine sarcoma virus.J Virol. 1982 Feb;41(2):735-43. doi: 10.1128/JVI.41.2.735-743.1982. J Virol. 1982. PMID: 7077752 Free PMC article.
Cited by
-
Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos.BMC Biochem. 2002 Apr 4;3:6. doi: 10.1186/1471-2091-3-6. BMC Biochem. 2002. PMID: 12022922 Free PMC article.
-
Multiple enhancer domains in the 3' terminus of the Prague strain of Rous sarcoma virus.Nucleic Acids Res. 1984 Aug 24;12(16):6427-42. doi: 10.1093/nar/12.16.6427. Nucleic Acids Res. 1984. PMID: 6089114 Free PMC article.
-
Oncogenic genes and human malignancy.Yale J Biol Med. 1983 Mar-Apr;56(2):121-9. Yale J Biol Med. 1983. PMID: 6636835 Free PMC article.
-
Recombinational junctions of variants of Moloney murine sarcoma virus: generation and divergence of a mammalian transforming gene.J Virol. 1983 Feb;45(2):607-17. doi: 10.1128/JVI.45.2.607-617.1983. J Virol. 1983. PMID: 6300424 Free PMC article.
-
Generation of phenotypic diversity and progression in metastatic tumor cells.Cancer Metastasis Rev. 1984;3(1):25-42. doi: 10.1007/BF00047691. Cancer Metastasis Rev. 1984. PMID: 6370418 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
