doi: 10.1038/283733a0.
An immunoglobulin heavy-chain gene is formed by at least two recombinational events
- PMID: 6766532
- DOI: 10.1038/283733a0
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An immunoglobulin heavy-chain gene is formed by at least two recombinational events
Nature.
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Abstract
The events of B-cell differentiation can be reconstructed in part through an analysis of the organisation of heavy-chain gene segments in differentiated B cells. A mouse immunoglobulin alpha heavy-chain gene is composed of at least three noncontiguous germ-line DNA segments--a VH gene segment, a JH gene segment associated with the Cmu gene segment, and the C alpha gene segment. These gene segments are joined together by two distinct types of DNA rearrangements--a V-J joining and a CH switch.
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