doi: 10.1073/pnas.80.21.6510.
Ethanol acceptance as a function of genotype amounts of brain [Met]enkephalin
- PMID: 6579537
- PMCID: PMC390382
- DOI: 10.1073/pnas.80.21.6510
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Ethanol acceptance as a function of genotype amounts of brain [Met]enkephalin
Proc Natl Acad Sci U S A.
1983 Nov.
Abstract
Our results indicate a negative correlation between the amount of ethanol (10%) consumed and endogenous levels of brain [Met]enkephalin in C57BL/6J (alcohol-preferring) and DBA/2J (alcohol-nonpreferring) inbred mice strains. Additionally, it was found that 8 wk after 1-day starved groups of both C57BL/6J and DBA/2J mice were challenged with ethanol (10%) for 1-day acceptance, they had significantly lower levels of brain [Met]enkephalin compared with their nonalcohol-treated controls. These results suggest that the brain endogenous peptidyl opiates may play a crucial role in alcohol-seeking behavior.
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