doi: 10.1126/science.6574602.
Transcriptional regulation of globin gene expression in the human erythroid cell line K562
- PMID: 6574602
- DOI: 10.1126/science.6574602
Item in Clipboard
Transcriptional regulation of globin gene expression in the human erythroid cell line K562
Science.
.
Abstract
The effect of hemin on the rate of synthesis and the level of globin messenger RNA's in the human erythroid cell line K562 was examined by means of cloned hybridization probes specific for each of the human embryonic, fetal, and adult globin genes. Hemin increases both the rate of transcription and the level of accumulation of zeta-, epsilon-, gamma-, and alpha-globin messenger RNA's by a factor of 3 to 5. Thus, hemin induction of globin gene expression in K562 cells is at the level of transcription.
Similar articles
-
Effects of hemin on a lymphoblastoid cell line that expresses the human epsilon- and gamma-globin genes.Mol Cell Biochem. 1985 Sep;68(1):11-22. doi: 10.1007/BF00219384. Mol Cell Biochem. 1985. PMID: 3864007
-
Differential expression of the globin genes in human leukemia K562(S) cells induced to differentiate by hemin or butyric acid.Cancer Res. 1981 Jan;41(1):237-43. Cancer Res. 1981. PMID: 6934848
-
Differing responses of globin and glycophorin gene expression to hemin in the human leukemia cell line K562.Blood. 1982 Apr;59(4):738-46. Blood. 1982. PMID: 7037071
-
Genome activity and gene expression in avian erythroid cells.Int Rev Cytol. 1982;74:95-126. doi: 10.1016/s0074-7696(08)61170-5. Int Rev Cytol. 1982. PMID: 6181005 Review. No abstract available.
-
Erythroid-specific transcription.Curr Opin Hematol. 1998 Mar;5(2):145-50. doi: 10.1097/00062752-199803000-00010. Curr Opin Hematol. 1998. PMID: 9570708 Review.
Cited by
-
Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3' end processing in the human alpha 2 globin gene.EMBO J. 1986 Nov;5(11):2915-22. doi: 10.1002/j.1460-2075.1986.tb04587.x. EMBO J. 1986. PMID: 3024968 Free PMC article.
-
Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.Proc Natl Acad Sci U S A. 1983 Dec;80(24):7551-5. doi: 10.1073/pnas.80.24.7551. Proc Natl Acad Sci U S A. 1983. PMID: 6200877 Free PMC article.
-
Stable gene transfer and tissue-specific expression of a human globin gene using adenoviral vectors.EMBO J. 1986 Sep;5(9):2377-85. doi: 10.1002/j.1460-2075.1986.tb04507.x. EMBO J. 1986. PMID: 3780679 Free PMC article.
-
Tissue specific transcription of the human epsilon-globin gene following transfection into the embryonic erythroid cell line K562.Nucleic Acids Res. 1985 Sep 11;13(17):6125-36. doi: 10.1093/nar/13.17.6125. Nucleic Acids Res. 1985. PMID: 2995916 Free PMC article.
-
DNA replication facilitates the action of transcriptional enhancers in transient expression assays.Nucleic Acids Res. 1993 Sep 11;21(18):4296-304. doi: 10.1093/nar/21.18.4296. Nucleic Acids Res. 1993. PMID: 8414985 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
