doi: 10.1111/j.1440-1681.1984.tb00878.x.
Interaction of choline with nicotinic and muscarinic cholinergic receptors in the rat brain in vitro
- PMID: 6536422
- DOI: 10.1111/j.1440-1681.1984.tb00878.x
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Interaction of choline with nicotinic and muscarinic cholinergic receptors in the rat brain in vitro
Clin Exp Pharmacol Physiol.
1984 Nov-Dec.
Abstract
The ability of choline to interact with nicotinic receptors was investigated by measuring its ability to inhibit the specific binding of [3H]-nicotine in rat brain. Choline, with an IC50 of 241 mumol/l, was three times more potent than its analogue deanol and almost 1000-fold less potent than acetylcholine. Choline also inhibited the binding of the antagonist [3H]-quinuclidinyl benzilate (IC50 = 2.5 mmol/l) and of the agonist [3H]-oxotremorine-M (IC50 = 165 mumol/l) to muscarinic cholinergic receptors. These results indicate that choline is able to interact directly, in vitro with brain cholinergic receptors of both the nicotinic and muscarinic type.
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