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. 1984 Sep;45(3):674-8.
doi: 10.1128/iai.45.3.674-678.1984.

Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis)

D M Williams, J Schachter, M H Weiner, B Grubbs

Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis)

D M Williams et al. Infect Immun. 1984 Sep.

Abstract

In a murine model of chlamydial pneumonia employing murine Chlamydia trachomatis, immune serum given intranasally delayed death in nude (nu/nu) mice and prevented death in nu/+ mice. Serum-derived immunoglobulin G and A fractions and immune lavage fluid fractions containing immunoglobulins G and A were effective in producing protection when used to opsonize the murine C. trachomatis inoculum. In hyperclean mice (previously made germfree and then colonized with a limited flora nonpathogenic to mice) antibody given intravenously was ineffective. The effects of antibody and nonspecific stimulation of cell-mediated immunity (after previous infection with Histoplasma capsulatum) were additive in increasing host resistance to murine C. trachomatis.

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