Biological effects of heat
- PMID: 6467224
Biological effects of heat
Abstract
The biological effects of heat appear to be favorable for its use to treat cancer. Heat kills cells in a predictable and repeatable way. The age response function complements X-rays in that S-phase cells are most sensitive, and at the same time cells that are at low pH or are nutritionally deprived are also more sensitive. This offers the possibility that cycling tumor cells and quiescent cells that have respired to hypoxia may be more sensitive to heat than are the slowly turning over cells of the normal tissues responsible for late effects. Thermotolerance, in general, represents a problem and a complication in clinical practice but may be exploited to advantage. The interaction of heat with ionizing radiation has been studied extensively and is complex; in general, heat inhibits the repair of both sublethal and potentially lethal X-ray damage, but it is not obvious how to exploit this to advantage. By contrast, the potentiation by heat of the action of chemotherapy agents has been relatively neglected. This is a promising area, since local hyperthermia can "target" drug action in a way not otherwise possible. Heat is a weak mutagen and has not been shown to be a carcinogen; this is a most desirable property at a time of increasing concern for the oncogenic potential of agents used to treat cancer.
Similar articles
-
Hyperthermic killing and hyperthermic radiosensitization in Chinese hamster ovary cells: effects of pH and thermal tolerance.Radiat Res. 1984 Jan;97(1):108-31. Radiat Res. 1984. PMID: 6695037
-
Effect of hypoxia on recovery from damage induced by heat and radiation in plateau-phase CHO cells.Radiat Res. 1985 Feb;101(2):312-25. Radiat Res. 1985. PMID: 3975360
-
Analysis of the heat and radiation interaction.Radiat Res. 1986 Sep;107(3):287-95. Radiat Res. 1986. PMID: 3749463
-
Biological rationale for hyperthermia in cancer treatment (II).Neoplasma. 1994;41(5):277-83. Neoplasma. 1994. PMID: 7854498 Review.
-
Thermal enhancement of cellular radiation damage: a review of complementary and synergistic effects.Scanning Microsc. 1988 Mar;2(1):513-35. Scanning Microsc. 1988. PMID: 3285465 Review.
Cited by
-
CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels?Eur Radiol. 2013 Aug;23(8):2215-27. doi: 10.1007/s00330-013-2825-y. Epub 2013 Apr 4. Eur Radiol. 2013. PMID: 23553588 Free PMC article.
-
Adverse effect of mild temperature hyperthermia combined with hexamethylenetetramine compared to its effect combined with tirapazamine in the treatment of solid tumors.Exp Ther Med. 2010 Jan;1(1):169-174. doi: 10.3892/etm_00000027. Epub 2010 Jan 1. Exp Ther Med. 2010. PMID: 23136610 Free PMC article.
-
The oncogenic potential of a combination of hyperthermia and chemotherapy agents.Br J Cancer. 1988 Jan;57(1):59-63. doi: 10.1038/bjc.1988.9. Br J Cancer. 1988. PMID: 3126790 Free PMC article.
-
The interplay of blood flow and temperature in regional hyperthermia: a mathematical approach.R Soc Open Sci. 2021 Jan 13;8(1):201234. doi: 10.1098/rsos.201234. eCollection 2021 Jan. R Soc Open Sci. 2021. PMID: 33614070 Free PMC article.
-
Effects of tumor necrosis factor and hyperthermia on Meth-A tumors.Jpn J Cancer Res. 1991 Oct;82(10):1171-4. doi: 10.1111/j.1349-7006.1991.tb01773.x. Jpn J Cancer Res. 1991. PMID: 1955383 Free PMC article.