Comparative Study
doi: 10.1038/312724a0.
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
- PMID: 6392892
- DOI: 10.1038/312724a0
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Comparative Study
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
Nature.
1984.
Abstract
Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.
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