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. 1984 May;309(5965):276-9.
doi: 10.1038/309276a0.

Long terminal repeats of human T-cell leukaemia virus II genome determine target cell specificity

I S Chen, J McLaughlin, D W Golde

Long terminal repeats of human T-cell leukaemia virus II genome determine target cell specificity

I S Chen et al. Nature. 1984 May.

Abstract

Human T-cell leukaemias and lymphomas associated with the human T-cell leukaemia viruses (HTLV) are invariably neoplasms of cells with mature T-lymphocyte phenotype. Epstein-Barr virus-transformed B- lymphoycte lines which are productively infected with HTLV may be isolated from patients with HTLV malignancies, but no non-lymphoid tissues seem to be involved. Here, to investigate the basis for this tissue specificity, we introduced type II HTLV (HTLV-II) into a variety of human cells by infection and also by transfection of recombinant genomes. We found no HTLV-II expression in non-lymphoid tissues although expression and correct initiation of transcription was observed in B and T lymphocytes. Our results using recombinant genomes indicate that the restriction of expression is at least partly due to cis-acting functions of the long terminal repeats which lie at each end of the HTLV genome.

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