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. 1984 Feb;49(2):598-600.
doi: 10.1128/JVI.49.2.598-600.1984.

Involvement of DNA polymerase alpha in host cell reactivation of UV-irradiated herpes simplex virus

Y Nishiyama, S Yoshida, K Maeno

Involvement of DNA polymerase alpha in host cell reactivation of UV-irradiated herpes simplex virus

Y Nishiyama et al. J Virol. 1984 Feb.

Abstract

Aphidicolin is a potent inhibitor of both host cell DNA polymerase alpha and herpes simplex virus (HSV)-induced DNA polymerase but has no effect on DNA polymerases beta and gamma of host cells. By using an aphidicolin-resistant mutant (Aphr) of HSV, a possible involvement of DNA polymerase alpha in host cell reactivation of UV-damaged HSV was studied. Plaque formation by UV-irradiated Aphr was markedly inhibited by 1 microgram of aphidicolin per ml, which did not affect the plating efficiency of nonirradiated Aphr. Aphidicolin added before 12 h postinfection inhibited plaque formation by irradiated Aphr, which became aphidicolin insensitive after 36 h postinfection. The results strongly suggest that host cell DNA polymerase alpha is involved in the repair of UV-irradiated HSV DNA.

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