Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978;6(1):16-20.
doi: 10.1007/BF01641085.

Amphotericin B concentrations in saliva after application of 2% amphotericin B in orabase

H G de Vries-Hospers, D van der Waaij

Amphotericin B concentrations in saliva after application of 2% amphotericin B in orabase

H G de Vries-Hospers et al. Infection. 1978.

Abstract

2% amphotericin B in orabase was applied to the buccal mucous membranes of healthy volunteers. Amounts of 1 g and 0.5 g were used. The experiments were performed during the day time as well as during the sleeping hours at night. At several intervals after application saliva samples were collected and the amphotericin B concentrations were determined. Application of 1 g of orabase with 2% amphotericin B appears to maintain a sufficiently high concentration for four hours, 0.5 g for three hours. Application of these amounts before going to sleep guarantees a sufficient concentration until awakening the next morning.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Ann Intern Med. 1972 Nov;77(5):707-14 - PubMed
    1. Infection. 1977;5(2):107-14 - PubMed
    1. Analyst. 1976 May;101(1202):321-40 - PubMed
    1. Chemotherapia (Basel). 1961;3:108-19 - PubMed
    1. Arch Oral Biol. 1973 Sep;18(9):1131-43 - PubMed