Comparative Study
doi: 10.1038/305605a0.
Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor
- PMID: 6312326
- DOI: 10.1038/305605a0
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Comparative Study
Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor
Nature.
1983 Oct.
Abstract
The predicted amino acid sequence of the simian sarcoma virus (SSV) transforming gene product, p28sis, closely corresponds to that of human platelet-derived growth factor (PDGF). We demonstrate that p28sis rapidly undergoes a series of discrete processing steps including dimer formation and proteolytic digestion to yield molecules structurally and immunologically resembling biologically active PDGF.
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