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Comparative Study
. 1983;2(2):173-80.

Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells

O Fasano, E Taparowsky, J Fiddes, M Wigler, M Goldfarb
  • PMID: 6308118
Comparative Study

Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells

O Fasano et al. J Mol Appl Genet. 1983.

Abstract

We have molecularly cloned and sequenced cDNA to the transcript of H-ras-1, the transforming gene of the T24 human bladder carcinoma cell line. The transcript derives from at least five exons in the H-ras-1 gene, and RNA splicing occurs at sites typical of exon-intron junctions. T24 H-ras-1 RNA has an AUG-initiated open reading frame of 567 nucleotides, which can encode a protein of mass comparable to the apparent molecular weight of the T24 H-ras-1 gene product. The T24 H-ras-1 gene product is nearly identical to v-H-ras p21, the transforming protein encoded by the genome of Harvey sarcoma virus. We discuss the implications of this sequence conservation in the structure-function relationships of ras proteins.

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