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Comparative Study
. 1983 Jan;45(1):104-13.
doi: 10.1128/JVI.45.1.104-113.1983.

Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T

I S Chen, K C Wilhelmsen, H M Temin
Comparative Study

Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T

I S Chen et al. J Virol. 1983 Jan.

Abstract

The cellular homolog of the onc sequences in the avian retrovirus reticuloendotheliosis virus strain T (v-rel) was studied by molecular cloning and nucleic acid hybridization. In contrast to v-rel sequences, which are 1.4 kilobase pairs long, the cellular homolog, c-rel, from line 15B chickens is at least 25 kilobase pairs long, with multiple apparent introns. A 4.0-kilobase polyadenylic acid-containing RNA transcript is the primary species of c-rel RNA present in uninfected chicken cells. Sequences at the 3' end of this c-rel RNA are not present in v-rel.

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