doi: 10.1038/298240a0.
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
- PMID: 6283379
- DOI: 10.1038/298240a0
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Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
Nature.
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Abstract
Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression.
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