Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1982;71(1):57-74.
doi: 10.1007/BF01315175.

Electron microscopic studies of bovine viral diarrhea virus in tissues of diseased calves and in cell cultures

H Bielefeldt Ohmann, B Bloch
Comparative Study

Electron microscopic studies of bovine viral diarrhea virus in tissues of diseased calves and in cell cultures

H Bielefeldt Ohmann et al. Arch Virol. 1982.

Abstract

Pathomorphological studies by electron microscopy (EM) were carried out on the intestines and lymphoid tissues, the buffy coat cells and cultured lymphocytes from calves suffering from mucosal disease (MD). This led to the detection of particles, 45--55 nm in diameter, within characteristic vesicular structures. As these findings coincided with the isolation of bovine viral diarrhea virus (BVDV) from the same tissues and demonstration of BVDV-antigen by immunocytochemical techniques in corresponding samples, the particles were tentatively identified as the BVDV. A detailed study of in vitro infected bovine cell cultures corroborated this supposition and contributed to a conjectural evaluation of the viral morphogenesis. It revealed a difference from the morphogenesis of most other togaviruses, as the presumed virions were assembled within smooth-membraned vesicles, formed during the infection. Thus, in the material examined, a budding process was not involved in the development of BVDV.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Virol. 1968 Jan;2(1):26-32 - PubMed
    1. Intervirology. 1978;9(3):129-48 - PubMed
    1. Nature. 1962 Jun 2;194:893-4 - PubMed
    1. Nature. 1977 Apr 28;266(5605):835-7 - PubMed
    1. Virology. 1965 Jul;26:512-6 - PubMed

Publication types

LinkOut - more resources