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. 1980 Oct 15;26(4):477-82.
doi: 10.1002/ijc.2910260413.

Herpesvirus saimiri: protective effect of attenuated strain against lymphoma induction

J Wright, L A Falk, L G Wolfe, F Deinhardt

Herpesvirus saimiri: protective effect of attenuated strain against lymphoma induction

J Wright et al. Int J Cancer. .

Abstract

An attenuated strain of Herpesvirus saimiri (A-HVS) induced a persistent, latent infection in common marmosets. Virus was recovered from circulating lymphocytes of infected animals and antibody response to virus-specified antigens was demonstrated over 3-12 months PI. A-HVS-infected common marmosets and animals without previous A-HVS exposure were challenged with oncogenic HVS (125-825 PFU); marmosets without A-HVS infection developed malignant lymphoproliferative disease and died 3 weeks PI whereas all persistently-infected animals have survived 38-43 months post challenge.

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