doi: 10.1126/science.6258226.
Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances
- PMID: 6258226
- DOI: 10.1126/science.6258226
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Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances
Science.
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Abstract
Kinetic analysis of the uptake of carbon-14-labeled oleate in a single-pass perfusion of rat liver and saturable and specific binding of iodine-125-labeled albumin to hepatocytes in suspension suggest the existence of a receptor for albumin on the liver cell surface. The putative receptor appears to mediate uptake of albumin-bound fatty acids by the cell and may account for the efficient hepatic extraction of many other substances tightly bound to albumin.
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