doi: 10.1038/284555a0.
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
- PMID: 6245367
- DOI: 10.1038/284555a0
Item in Clipboard
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
Nature.
.
Abstract
In near-physiological concentrations, glucocorticoid hormones cause the death of several types of normal and neoplastic lymphoid cell, but the mechanisms involved are unknown. One of the earliest structural changes in the dying cell is widespread chromatin condensation, of the type characteristic of apoptosis, the mode of death frequently observed where cell deletion seems to be 'programmed'. It is shown here that this morphological change is closely associated with excision of nucleosome chains from nuclear chromatin, apparently through activation of an intracellular, but non-lysosomal, endonuclease.
Similar articles
-
Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.J Pathol. 1984 Jan;142(1):67-77. doi: 10.1002/path.1711420112. J Pathol. 1984. PMID: 6422024
-
The condensation of chromatin in apoptotic thymocytes shows a specific structural change.J Biol Chem. 1997 Apr 18;272(16):10817-22. doi: 10.1074/jbc.272.16.10817. J Biol Chem. 1997. PMID: 9099736
-
Apoptosis. The role of the endonuclease.Am J Pathol. 1990 Mar;136(3):593-608. Am J Pathol. 1990. PMID: 2156431 Free PMC article.
-
The apoptosis endonuclease and its regulation.Semin Immunol. 1992 Dec;4(6):389-97. Semin Immunol. 1992. PMID: 1337478 Review.
-
Glucocorticoid-induced apoptosis in the thymus.Semin Immunol. 1992 Dec;4(6):363-9. Semin Immunol. 1992. PMID: 1286164 Review.
Cited by
-
Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway.PLoS One. 2016 May 2;11(5):e0154023. doi: 10.1371/journal.pone.0154023. eCollection 2016. PLoS One. 2016. PMID: 27136097 Free PMC article.
-
Induced neural stem cells protect neuronal cells against apoptosis.Med Sci Monit. 2014 Dec 22;20:2759-66. doi: 10.12659/MSM.891343. Med Sci Monit. 2014. PMID: 25554259 Free PMC article.
-
Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis.Cell Res. 2016 Sep;26(9):1007-20. doi: 10.1038/cr.2016.100. Epub 2016 Aug 30. Cell Res. 2016. PMID: 27573174 Free PMC article.
-
Extrachromosomal DNA (ecDNA): Unveiling its role in cancer progression and implications for early detection.Heliyon. 2023 Oct 29;9(11):e21327. doi: 10.1016/j.heliyon.2023.e21327. eCollection 2023 Nov. Heliyon. 2023. PMID: 38027570 Free PMC article. Review.
-
Green-Synthesized Silver Nanoparticles Induced Apoptotic Cell Death in MCF-7 Breast Cancer Cells by Generating Reactive Oxygen Species and Activating Caspase 3 and 9 Enzyme Activities.Oxid Med Cell Longev. 2020 Oct 5;2020:1215395. doi: 10.1155/2020/1215395. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 33082906 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
