Immunology of cytomegalovirus: immunosuppressive effects during infections
- PMID: 6203569
Immunology of cytomegalovirus: immunosuppressive effects during infections
Abstract
Acute CMV infection in the mouse results in depressed antibody production, IFN induction, lymphocyte proliferation responses to mitogens, allogeneic skin graft rejection, and clearance of certain bacteria and fungi from the blood stream. CMV mononucleosis in humans is associated with decreased lymphocyte proliferation responses to mitogens and herpesvirus antigens, decreased IFN production, and reversal of the T-helper to suppressor cell ratio. In recent studies, we have shown that NK activity is depressed after renal transplantation and the use of cyA, and is poorly enhanced by the addition of IFN to in vitro assays. In vitro induction of alpha-IFN as well as gamma-IFN by NDV and enterotoxin-A is also inhibited. These deficits may contribute to the severity of CMV infections in this patient population.
Similar articles
-
High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function.Transpl Immunol. 2009 Mar;20(4):238-42. doi: 10.1016/j.trim.2008.11.002. Epub 2008 Nov 24. Transpl Immunol. 2009. PMID: 19032982
-
Maintenance of cytomegalovirus (CMV) latency and host immune responses of long term renal allograft survivors. II. Secondary CMV infections associated with impaired in vitro proliferative responses to mitogens, allogeneic lymphocytes and CMV infected cells.Clin Exp Immunol. 1985 Jul;61(1):72-9. Clin Exp Immunol. 1985. PMID: 2994923 Free PMC article.
-
Evaluation of cytomegalovirus-specific T-cell reconstitution in patients after various allogeneic haematopoietic stem cell transplantation using interferon-gamma-enzyme-linked immunospot and human leucocyte antigen tetramer assays with an immunodominant T-cell epitope.Br J Haematol. 2005 Nov;131(4):472-9. doi: 10.1111/j.1365-2141.2005.05800.x. Br J Haematol. 2005. PMID: 16281937
-
Natural killer cells and lung transplantation, roles in rejection, infection, and tolerance.Transpl Immunol. 2008 Apr;19(1):1-11. doi: 10.1016/j.trim.2008.01.004. Epub 2008 Feb 20. Transpl Immunol. 2008. PMID: 18346631 Review.
-
Immunosuppressive agents and cytomegalovirus infection.Arch Immunol Ther Exp (Warsz). 2003;51(3):179-84. Arch Immunol Ther Exp (Warsz). 2003. PMID: 12894872 Review.
Cited by
-
Monocyte-derived inhibitor of interleukin 1 induced by human cytomegalovirus.J Virol. 1985 Sep;55(3):527-32. doi: 10.1128/JVI.55.3.527-532.1985. J Virol. 1985. PMID: 2991578 Free PMC article.
-
The impact of CMV on the respiratory burst of macrophages in response to Pneumocystis carinii.Clin Exp Immunol. 2001 Feb;123(2):239-46. doi: 10.1046/j.1365-2249.2001.01465.x. Clin Exp Immunol. 2001. PMID: 11207654 Free PMC article.
-
Restoration of immunological responses by THF, a thymic hormone, in mice infected with murine cytomegalovirus (MCMV).Clin Exp Immunol. 1987 Nov;70(2):268-75. Clin Exp Immunol. 1987. PMID: 2448072 Free PMC article.
-
Effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection.Antimicrob Agents Chemother. 1985 Oct;28(4):485-8. doi: 10.1128/AAC.28.4.485. Antimicrob Agents Chemother. 1985. PMID: 3000290 Free PMC article.
-
First two bilateral hand transplantations in India (Part 2): Technical details.Indian J Plast Surg. 2017 May-Aug;50(2):153-160. doi: 10.4103/ijps.IJPS_94_17. Indian J Plast Surg. 2017. PMID: 29343890 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical