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. 1982 Aug;79(15):4599-603.
doi: 10.1073/pnas.79.15.4599.

Three-dimensional structural model of eubacterial 5S RNA that has functional implications

T Pieler, V A Erdmann

Three-dimensional structural model of eubacterial 5S RNA that has functional implications

T Pieler et al. Proc Natl Acad Sci U S A. 1982 Aug.

Abstract

Escherichia coli 5S RNA and its specific protein complexes were hydrolyzed with the single-strand-specific nuclease S1. Based on the results, a tertiary structural model for E. coli 5S RNA is proposed in which ribosomal proteins E-L5, E-L18, and E-L25 influence the conformation of the RNA. This may be of significance for ribosomal function. Comparison of the proposed E. coli 5S RNA structure with those of 18 other prokaryotic 5S RNAs led to a generalized eubacterial 5S RNA tertiary structure in which the majority of the conserved nucleotides are in non-base-paired regions and several conserved "looped-out" adenines (in E. coli, adenines -52, -53, -57, -58, and -66) are implied to be important for protein recognition or interaction or both.

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